(Bloomberg) -- The hallucinogen ketamine relieved symptoms of hard-to-treat depression within a day of treatment, in the largest study yet of the popular club drug’s use in psychiatry.

In the trial of 72 people whose depression hadn’t responded to at least two antidepressants, patients taking ketamine were twice as likely to report improvement than those on a placebo. The study, by researchers at the Baylor College of Medicine in Houston and Mount Sinai School of Medicine in New York, assessed patients after one day and again a week later.

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